Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing

被引：115

作者：

Fedyk, ER

Jones, D

Critchley, HOD

Phipps, RP

Blieden, TM

Springer, TA

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA

[2] Univ Edinburgh, Ctr Reprod Biol, Dept Reprod & Dev Sci, Edinburgh EH3 9EW, Midlothian, Scotland

[3] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

[4] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA

[5] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA

[6] Univ Rochester, Sch Med & Dent, Ctr Canc, Rochester, NY 14642 USA

[7] Univ Rochester, Eastman Dent Ctr, Dept Periodontol, Rochester, NY 14627 USA

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 166卷 / 09期

关键词：

D O I：

10.4049/jimmunol.166.9.5749

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we demonstrate that dermal fibroblasts and vessels of noninflamed tissues express SDF-1. Unexpectedly, we found that expression of SDF-1 is regulated by inflammation. Expression of SDF-1 by primary cultures of human gingival fibroblasts is potently inhibited by activated macrophages via secretion of IL-1 alpha and TNF-alpha. Levels of SDF-1 mRNA also decrease in acutely inflamed mouse dermal wounds. We propose that SDF-1 functions as a homeostatic regulator of tissue remodeling, whose expression stabilizes existing dermal architecture.

引用

页码：5749 / 5754

页数：6

共 23 条

[1] The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].