SECISDesign: a server to design SECIS-elements within the coding sequence

被引：7

作者：

Busch, A ^{[1
]}

Will, S ^{[1
]}

Backofen, R ^{[1
]}

机构：

[1] Univ Jena, Inst Comp Sci, Chair Bioinformat, D-07743 Jena, Germany

来源：

BIOINFORMATICS | 2005年 / 21卷 / 15期

关键词：

D O I：

10.1093/bioinformatics/bti507

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

SECISDesign is a server for the design of SECIS-elements and arbitrary RNA-elements within the coding sequence of an mRNA. The element has to satisfy both structure and sequence constraints. At the same time, a certain amino acid similarity to the original protein has to be kept. The designed sequence can be used for recombinant expression of selenoproteins in Escherichia coli. Availability: The server is available at http://www.bio.inf.uni-jena.de/Software/SECISDesign/index.html Contact: <EMAILREF>backofen@inf.uni-jena.de

引用

页码：3312 / 3313

页数：2

共 5 条

[1]

BACKOFEN R, 2004, P 15 ANN S COMB PATT

[2] Mouse methionine sulfoxide reductase B: effect of selenocysteine incorporation on its activity and expression of the seleno-containing enzyme in bacterial and mammalian cells [J].

Bar-Noy, S ;

Moskovitz, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 297 (04) :956-961

[3]

Brown K M, 2001, Public Health Nutr, V4, P593

[4] Paradigms for computational nucleic acid design [J].

Dirks, RM ;

Lin, M ;

Winfree, E ;

Pierce, NA .

NUCLEIC ACIDS RESEARCH, 2004, 32 (04) :1392-1403

[5] FAST FOLDING AND COMPARISON OF RNA SECONDARY STRUCTURES [J].

HOFACKER, IL ;

FONTANA, W ;

STADLER, PF ;

BONHOEFFER, LS ;

TACKER, M ;

SCHUSTER, P .

MONATSHEFTE FUR CHEMIE, 1994, 125 (02) :167-188

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