Interaction of chiral MS-245 analogs at h5-HT6 receptors

被引：18

作者：

Abate, C

Kolanos, R

Dukat, M

Setola, V

Roth, BL

Glennon, RA ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Med Chem, Sch Pharm, Richmond, VA 23298 USA

[2] Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Psychiat & Neurosci, Sch Med, Cleveland, OH 44106 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 15期

关键词：

serotonin; pyrrolidinylmethylindoles;

D O I：

10.1016/j.bmcl.2005.05.092

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optically active pyrrolidinylmethylindole analogs related in structure to the benzenesulfonyltryptantine 5-HT6 receptor antagonist MS-245 were evaluated and their R-isomers were found to bind with affinity higher than their S-enantiomers. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3510 / 3513

页数：4

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