Newly discovered endocrine functions of white adipose tissue: possible relevance in obesity-related diseases

被引：25

作者：

Krug, AW ^{[1
]}

Ehrhart-Bornstein, M ^{[1
]}

机构：

[1] Univ Dresden, Carl Gustav Carus Univ Hosp, Dept Med, D-01307 Dresden, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 12期

关键词：

adipose tissue; adipocyte; obesity; endocrine; adipokines; inflammation; hypertension;

D O I：

10.1007/s00018-005-4555-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During recent years our view of adipose tissue has been revolutionized. White adipose tissue (WAT) is no longer seen as mere energy store or provider of thermal and mechanical insulation. Neglect of WAT has been overcome by surprising discoveries in recent years, changing the view of this tissue towards a highly endocrine organ that is involved in a wide variety of physiological and pathophysiological processes. In this brief article we will focus on new developments in adipocyte and WAT biology. The appreciation of WAT as an endocrine organ will provide the basis for new and promising perspectives in the management of obesity and obesity-related diseases including diabetes, mellitus type II and arterial hypertension.

引用

页码：1359 / 1362

页数：4

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