Accumulation of tyrosine hydroxylase messenger RNA molecules in the rat mesencephalon by chronic caffeine treatment

被引:10
作者
Datta, U [1 ]
Noailles, PAH [1 ]
Rodriguez, M [1 ]
Kraft, M [1 ]
Zhang, Y [1 ]
Angulo, JA [1 ]
机构
[1] CUNY HUNTER COLL,DEPT BIOL SCI,NEW YORK,NY 10021
关键词
tyrosine hydroxylase mRNA; caffeine; MK-801; ventral tegmental area; substantia nigra compacta;
D O I
10.1016/S0304-3940(96)13213-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the present study we assessed the effect of chronic treatment with caffeine on the levels of the messenger RNA molecule encoding the enzyme tyrosine hydroxylase (TH) by in situ hybridization histochemistry in the ventral tegmental area (VTA) and the substantia nigra compacta (SNc) of the rat brain. Animals that received caffeine for nine consecutive days at doses of 20, 40 and 80 mg/kg of body weight displayed increased TH mRNA levels in the SNc (up to 64% above vehicle-injected controls) and the VTA (33% above controls). Moreover, the increases observed at 80 mg/kg of caffeine were prevented by concurrent administration of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (0.25 mg/kg). These results demonstrate that chronic exposure to caffeine, an adenosine A2 receptor antagonist, alters the levels of expression of the mRNA encoding the rate limiting enzyme in catecholamine biosynthesis. Copyright (C) 1996 Elsevier Science Ireland Ltd.
引用
收藏
页码:77 / 80
页数:4
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