A clinicopathological aspect of chorionic villous hemorrhage leading to formation of intervillous thrombosis

被引:3
作者
Soma, H [1 ]
Watanabe, Y [1 ]
Osawa, H [1 ]
Hata, T [1 ]
机构
[1] Saitama Med Sch, Dept Obstet & Gynecol, Iruma, Saitama 3500451, Japan
关键词
intervillous thrombosis; chorangiosis; chorionic villous hemorrhage; placental abruption; feto-maternal blood mixture;
D O I
10.1055/s-2007-996046
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recently it was reported that chorionic villous hemorrhage (CVH) had a significant association with retroplacental hemorrhage (RPH). In this study, to determine whether CVH has a correlation with RPH or intervillous thrombosis (IVT), placentas associated with CVH were clinico-histopathologically investigated and compared to those with IVT. Obstetric complications in 32 cases with CVH were compared with 258 cases with IVT. Placental abruption was significantly higher (18.7%) in the CVH group than in the IVT group (5.03%) and the incidences of intrauterine fetal death (IUFD) as well as intrauterine growth retardation (IUGR) were also significantly higher (18.7% and 9.37%) in the CVH group than in the IVT group (3.10% and 2.32%). Of the pathological characteristics of the placentas with CVH, IVT was found in 46.8%, but marginal or retroplacental hemorrhages were seen in 34.3%, compared to 14.2% of the IVT group. Premature infants with low birth weight (under 2000 g) and before 36 weeks of gestation were born in 53.1 % and 34.3 % of cases with CVH placentas. CVH was not only located near the basal plate of the placentas and decidual hemorrhages, but was also highly associated with chorangiosis in 75% of cases. Using histological and ultrastructural studies in CVH cases, villous stroma was filled with fetal erythrocytes and leakage of blood cells was observed through a disruption of the trophoblast layer of hemorrhagic villi. In conclusion, it is suggested that CVH may rather be related to formation of the intervillous thrombosis than to RPH.
引用
收藏
页码:497 / 501
页数:5
相关论文
共 14 条
  • [1] ALTSHULER G, 1984, ARCH PATHOL LAB MED, V108, P71
  • [2] ASTEDT B, 1986, THROMB HAEMOSTASIS, V56, P63
  • [3] BATCUP G, 1983, PLACENTA, V4, P449
  • [4] Two fetal deaths associated with maternal sepsis and with thrombosis of the intervillous space of the placenta
    Bendon, RW
    Bornstein, S
    Faye-Petersen, OM
    [J]. PLACENTA, 1998, 19 (5-6) : 385 - 389
  • [5] FOX H, 1978, PATHOLOGY PLACENTA, P123
  • [6] IDENTIFICATION OF ERYTHROCYTES IN INTERVILLOUS THROMBI - A STUDY USING IMMUNOPEROXIDASE IDENTIFICATION OF HEMOGLOBINS
    KAPLAN, C
    BLANC, WA
    ELIAS, J
    [J]. HUMAN PATHOLOGY, 1982, 13 (06) : 554 - 557
  • [7] Placental pathology in patients using cocaine: An observational study
    Mooney, EE
    Boggess, KA
    Herbert, WNP
    Layfield, LJ
    [J]. OBSTETRICS AND GYNECOLOGY, 1998, 91 (06) : 925 - 929
  • [8] CHORIONIC VILLOUS HEMORRHAGE IS ASSOCIATED WITH RETROPLACENTAL HEMORRHAGE
    MOONEY, EE
    ALSHUNNAR, A
    OREGAN, M
    GILLAN, JE
    [J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1994, 101 (11): : 965 - 969
  • [9] MUKAIDA T, 1978, J CLIN ELECT MICROSC, V11, P5
  • [10] NAEYE RL, 1992, DISORDERS PLACENTA F, P180