Reaction of carboxylic acids with diethyl phosphorocyanidate;: A novel synthesis of homologated α-hydroxycarboxylic acids from carboxylic acids

被引：11

作者：

Mizuno, M

Shioiri, T

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Eisai & Co Ltd, Proc Res Labs, Hazaki, Ibaraki 3140255, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

carboxylic acids; homologation; hydroxy acids; cyano compounds;

D O I：

10.1016/S0040-4039(98)02099-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carboxylic acids react with 2 equivalents of diethyl phosphorocyanidate in the presence of triethylamine to give dicyanophosphates in good yields; these dicyanophosphates can be hydrolyzed easily to give homologated alpha-hydroxycarboxylic acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9209 / 9210

页数：2

共 3 条

[1] THE CHEMISTRY OF ACYL CYANIDES [J].