Multicomponent Lyme vaccine:: Three is not a crowd

被引:43
作者
Brown, EL [1 ]
Kim, JH [1 ]
Reisenbichler, ES [1 ]
Höök, M [1 ]
机构
[1] Texas A&M Univ, Syst Hlth Sci Ctr, Ctr Etracellular Matrix Biol, Albert B Alkek Inst Biosci & Technol, Houston, TX 77030 USA
关键词
Lyme disease; prozone; vaccine; Borrelia burgdorferi;
D O I
10.1016/j.vaccine.2005.02.006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lyme disease is caused by the spirochete Borrelia burgdorferi and it is the most common vector-borne disease in the United States. Disseminated spirochetes can persist in various tissues and can result in a variety of different disease manifestations. Vaccination trials testing various lipoprotein candidates have yielded mixed results despite the generation of robust antibody titers. Data presented in this report demonstrate that a combination vaccine composed of DbpA, BBK32 and OspC is more effective than single or double component formulations and that the ratio of each component dramatically impacts vaccine efficacy when tested in protection experiments against Borrelia following needle inoculation. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3687 / 3696
页数:10
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