Cytotoxic trichilin-type limonoids from Melia azedarach

被引：36

作者：

Takeya, K ^{[1
]}

Qiao, ZS ^{[1
]}

Hirobe, C ^{[1
]}

Itokawa, H ^{[1
]}

机构：

[1] TOKYO UNIV PHARM & LIFE SCI,DEPT NAT MED,HACHIOJI,TOKYO 19203,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 08期

关键词：

D O I：

10.1016/0968-0896(96)00128-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new trichilin-type limonoids, named 12-deacetyltrichilin I (1), 1-acetyltrichilin H (2), 3-deacetyltrichilin H (3), 1-acetyl-3-deacetyltrichilin H (4), 1-acetyl-2-deacetyltrichilin H (5), together with four known trichilins, meliatoxin B-1 (6), trichilin H (7), trichilin D (8) and 1,12-diacetyltrichilin B (9) were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopic means and their cytotoxic activities against P388 cells in vitro were tested by means of MTT assay. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1355 / 1359

页数：5

共 14 条

[1] CYTOTOXIC LIMONOIDS FROM MELIA AZEDARACH VAR JAPONICA [J].

AHN, JW ;

CHOI, SU ;

LEE, CO .

PHYTOCHEMISTRY, 1994, 36 (06) :1493-1496

[2] MELIACINE, AN ANTIVIRAL COMPOUND FROM MELIA-AZEDARACH L, INHIBITS INTERFERON-PRODUCTION [J].

ANDREI, GM ;

COULOMBIE, FC ;

COURREGES, MC ;

DETORRES, RA ;

COTO, CE .

JOURNAL OF INTERFERON RESEARCH, 1990, 10 (05) :469-475

[3]

CARMICHAEL J, 1987, CANCER RES, V47, P936

[4] BIOLOGICAL-ACTIVITY OF LIMONOIDS FROM THE RUTALES [J].

CHAMPAGNE, DE ;

KOUL, O ;

ISMAN, MB ;

SCUDDER, GGE ;

TOWERS, GHN .

PHYTOCHEMISTRY, 1992, 31 (02) :377-394

[5] THE STRUCTURES OF AZEDARACHINS, LIMONOID ANTIFEEDANTS FROM CHINESE MELIA-AZEDARACH LINN [J].

HUANG, RC ;

OKAMURA, H ;

IWAGAWA, T ;

NAKATANI, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1994, 67 (09) :2468-2472

[6] AZEDARACHIN-C, A LIMONOID ANTIFEEDANT FROM MELIA-AZEDARACH [J].

HUANG, RC ;

OKAMURA, H ;

IWAGAWA, T ;

TADERA, K ;

NAKATANI, M .

PHYTOCHEMISTRY, 1995, 38 (03) :593-594

[7]

ITOKAWA H, 1995, CHEM PHARM BULL, V43, P1171, DOI 10.1248/cpb.43.1171

[8] ISOLATION AND STRUCTURES OF TRICHILINS, ANTIFEEDANTS AGAINST THE SOUTHERN ARMY WORM [J].

NAKATANI, M ;

JAMES, JC ;

NAKANISHI, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (05) :1228-1230

[9] STRUCTURES OF INSECT ANTIFEEDING LIMONOIDS, TRICHILINS F AND G, FROM TRICHILIA-ROKA [J].

NAKATANI, M ;

NAKANISHI, K .

HETEROCYCLES, 1993, 36 (04) :725-731

[10]

NAQVI S N H, 1991, Pakistan Journal of Pharmaceutical Sciences, V4, P71

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