The NMDA receptor complex as a therapeutic target in epilepsy: a review

被引：180

作者：

Ghasemi, Mehdi ^{[1
]}

Schachter, Steven C. ^{[2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

EPILEPSY & BEHAVIOR | 2011年 / 22卷 / 04期

关键词：

Epilepsy; Seizure; NMDA receptor; NMDA receptor antagonist; METHYL-D-ASPARTATE; AMINO-ACID ANTAGONISTS; TEMPORAL-LOBE EPILEPSY; REFRACTORY STATUS EPILEPTICUS; INSENSITIVE GLYCINE RECEPTOR; ETHANOL-WITHDRAWAL SEIZURES; CONVENTIONAL ANTIEPILEPTIC DRUGS; SUBUNIT MESSENGER-RNA; STRUCTURAL ANALOGS DIZOCILPINE; COCAINE-INDUCED CONVULSIONS;

D O I：

10.1016/j.yebeh.2011.07.024

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs) may play a key role in the pathophysiology of several neurological diseases, including epilepsy. Animal models of epilepsy and clinical studies demonstrate that NMDAR activity and expression can be altered in association with epilepsy and particularly in some specific seizure types. NMDAR antagonists have been shown to have antiepileptic effects in both clinical and preclinical studies. There is some evidence that conventional antiepileptic drugs may also affect NMDAR function. In this review, we describe the evidence for the involvement of NMDARs in the pathophysiology of epilepsy and provide an overview of NMDAR antagonists that have been investigated in clinical trials and animal models of epilepsy. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：617 / 640

页数：24

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