Cesium promoted O-alkylation of alcohols for the efficient ether synthesis

被引：62

作者：

Dueno, EE

Chu, FX

Kim, SI

Jung, KW

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Drug Discovery Program, Tampa, FL 33612 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 10期

关键词：

cesium carbonate and cesium hydroxide; TBAI; molecular sieves; O-alkylation of alcohols; hydroxyl protection;

D O I：

10.1016/S0040-4039(99)00083-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient Williamson type O-alkylation of alcohols was developed using cesium bases in the presence of tetrabutylammonium iodide (TBAI) and molecular sieves. Various substrates including unreactive primary and secondary alcohols were converted smoothly to the corresponding ethers. Electrophiles used herein encompass primary bromides and reactive halides such as benzyl bromide and MPMCl. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1843 / 1846

页数：4

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