Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering

被引：66

作者：

Ekenseair, Adam K. ^{[1
]}

Boere, Kristel W. M. ^{[1
]}

Tzouanas, Stephanie N. ^{[1
]}

Vo, Tiffany N. ^{[1
]}

Kasper, F. Kurtis ^{[1
]}

Mikos, Antonios G. ^{[1
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77030 USA

来源：

BIOMACROMOLECULES | 2012年 / 13卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

IN-SITU FORMATION; BIOMEDICAL APPLICATIONS; CROSS-LINKING; MACROMERS; DEGRADATION; POLY(AMIDO-AMINE)S; BIOMATERIALS; COPOLYMERS; POLYMERS; DELIVERY;

D O I：

10.1021/bm300429e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel, injectable hydrogels were developed that solidify through a physical and chemical dual-gelation mechanism upon preparation and elevation of temperature to 37 degrees C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolytically degradable polyamidoamine-based diamine cross-linker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxy-amine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine cross-linker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant postformation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability.

引用

页码：1908 / 1915

页数：8

共 37 条

[1] Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking [J].