A cyanobacterial circadian clockwork

被引:67
作者
Johnson, Carl Hirschie [1 ]
Mori, Tetsuya [1 ]
Xu, Yao [1 ]
机构
[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37240 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.cub.2008.07.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cyanobacteria have become a major model system for analyzing circadian rhythms. The temporal program in this organism enhances fitness in rhythmic environments and is truly global - essentially all genes are regulated by the circadian system. The topology of the chromosome also oscillates and possibly regulates the rhythm of gene expression. The underlying circadian mechanism appears to consist of both a post-translational oscillator (PTO) and a transcriptional/translational feedback loop (TTFL). The PTO can be reconstituted in vitro with three purified proteins (KaiA, KaiB, and KaiC) and ATP. These three core oscillator proteins have been crystallized and structurally determined, the only full-length circadian proteins to be so characterized. The timing of cell division is gated by a circadian checkpoint, but the circadian pacemaker is not influenced by the status of the cell division cycle. This imperturbability may be due to the presence of the PTO that persists under conditions in which metabolism is repressed. Recent biochemical, biophysical, and structural discoveries have brought the cyanobacterial circadian system to the brink of explaining heretofore unexplainable biochemical characteristics of a circadian oscillator: the long time constant, precision, and temperature compensation.
引用
收藏
页码:R816 / R825
页数:10
相关论文
共 81 条
  • [1] Cyanobacterial clock, a stable phase oscillator with negligible intercellular coupling
    Amdaoud, M.
    Vallade, M.
    Weiss-Schaber, C.
    Mihalcescu, I.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (17) : 7051 - 7056
  • [2] ACTIVITY RHYTHMS OF ENZYMES IN HUMAN RED BLOOD-CELL SUSPENSIONS
    ASHKENAZI, IE
    HARTMAN, H
    STRULOVITZ, B
    DAR, O
    [J]. JOURNAL OF INTERDISCIPLINARY CYCLE RESEARCH, 1975, 6 (04): : 291 - 301
  • [3] Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli
    Atkinson, MR
    Savageau, MA
    Myers, JT
    Ninfa, AJ
    [J]. CELL, 2003, 113 (05) : 597 - 607
  • [4] Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock
    Chabot, Jeffrey R.
    Pedraza, Juan M.
    Luitel, Prashant
    van Oudenaarden, Alexander
    [J]. NATURE, 2007, 450 (7173) : 1249 - 1252
  • [5] Functioning and robustness of a bacterial circadian clock
    Clodong, Sebastien
    Duehring, Ulf
    Kronk, Luiza
    Wilde, Annegret
    Axmann, Ilka
    Herzel, Hanspeter
    Kollmann, Markus
    [J]. MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1) : 1 - 9
  • [6] Dunlap J.C., 2003, CHRONOBIOLOGY BIOL T
  • [7] Molecular bases for circadian clocks
    Dunlap, JC
    [J]. CELL, 1999, 96 (02) : 271 - 290
  • [8] Hourglass model for a protein-based circadian oscillator
    Emberly, E
    Wingreen, NS
    [J]. PHYSICAL REVIEW LETTERS, 2006, 96 (03)
  • [9] Anabaena circadian clock proteins KaiA and KaiB reveal a potential common binding site to their partner KaiC
    Garces, RG
    Wu, N
    Gillon, W
    Pai, EF
    [J]. EMBO JOURNAL, 2004, 23 (08) : 1688 - 1698
  • [10] DINITROGEN-FIXING ENDOGENOUS RHYTHM IN SYNECHOCOCCUS RF-1
    GROBBELAAR, N
    HUANG, TC
    LIN, HY
    CHOW, TJ
    [J]. FEMS MICROBIOLOGY LETTERS, 1986, 37 (02) : 173 - 177