Proteolysis inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss

被引：64

作者：

Cabal-Manzano, R

Bhargava, P

Torres-Duarte, A

Marshall, J

Bhargava, P

Wainer, IW

机构：

[1] Georgetown Univ, Med Ctr, Lombardi Canc Ctr, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Div Clin Pharmacol, Washington, DC 20007 USA

[3] Georgetown Univ, Dept Pharmacol, Washington, DC 20007 USA

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 12期

关键词：

proteolysis-inducing factor; tumour expression; weight-loss; humans;

D O I：

10.1054/bjoc.2001.1830

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans. (C) 2001 Cancer Research Campaign.

引用

页码：1599 / 1601

页数：3

共 8 条

[1] ABC of palliative care - Anorexia, cachexia, and nutrition [J].