Genomes optimize reproduction: Aging as a consequence of the developmental program

被引：91

作者：

de Magalhaes, JP ^{[1
]}

Church, GM ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00010.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Natural selection shapes genomes for reproduction, not for postreproductive survival. One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein we review, revive, and refine the developmental theory of aging. Implications and experimental approaches for studying the progressive deterioration of physiological function that we call aging are also discussed.

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页码：252 / 259

页数：8

相关论文

共 54 条

[1] Growth patterns and the risk of breast cancer in women [J].

Ahlgren, M ;

Melbye, M ;

Wohlfahrt, J ;

Sorensen, TIA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (16) :1619-1626

[2]

[Anonymous], 1991, Evolutionary Biology of Aging

[3]

[Anonymous], 2013, DEV BIOL

[4] Fetal programming of coronary heart disease [J].

Barker, DJP .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (09) :364-368

[5] Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights [J].

Bartke, A ;

Chandrashekar, V ;

Dominici, F ;

Turyn, D ;

Kinney, B ;

Steger, R ;

Kopchick, JJ .

BIOGERONTOLOGY, 2003, 4 (01) :1-8

[6] Of mice and models: improved animal models for biomedical research [J].

Bockamp, E ;

Maringer, M ;

Spangenberg, C ;

Fees, S ;

Fraser, S ;

Eshkind, L ;

Oesch, F ;

Zabel, B .

PHYSIOLOGICAL GENOMICS, 2002, 11 (03) :115-132

[7] What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models? [J].

Brakefield, PM ;

Gems, D ;

Cowen, T ;

Christensen, K ;

Grubeck-Loebenstein, B ;

Keller, L ;

Oeppen, J ;

Rodriguez-Pena, A ;

Stazi, MA ;

Tatar, M ;

Westendorp, RGJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 2005, 126 (03) :431-438

[8] Muscle regeneration in amphibians and mammals: Passing the torch [J].

Carlson, BM .

DEVELOPMENTAL DYNAMICS, 2003, 226 (02) :167-181

[9] Genetics and the making of Homo sapiens [J].

Carroll, SB .

NATURE, 2003, 422 (6934) :849-857

[10]

Charnov Eric L., 1993, P1

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