Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of malignant ascites secondary to unresectable peritoneal carcinomatosis from advanced gastric cancer

被引：87

作者：

Facchiano, E. ^{[1
]}

Scaringi, S. ^{[1
]}

Kianmanesh, R. ^{[1
]}

Sabate, J. M. ^{[2
]}

Castel, B. ^{[1
]}

Flamant, Y. ^{[1
]}

Coffin, B. ^{[2
]}

Msika, S. ^{[1
]}

机构：

[1] Univ Paris 07, AP HP, Louis Mourier Hosp, Dept Surg, F-92701 Colombes, France

[2] Univ Paris 07, AP HP, Louis Mourier Hosp, Dept Hepatogastroenterol, F-92701 Colombes, France

来源：

EJSO | 2008年 / 34卷 / 02期

关键词：

laparoscopy; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis; ascites; gastric cancer;

D O I：

10.1016/j.ejso.2007.05.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims: To review our experience of laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of malignant ascites from advanced gastric cancer in order to discuss benefits, problems and possible indications. Methods: From June 2000 to May 2003 laparoscopic approach was used to perform HIPEC on five patients affected by malignant ascites secondary to unresectable peritoneal carcinomatosis of gastric origin, in order to associate the benefits of a definitive palliation of ascites with a minimal invasiveness. All patients had ascites related symptoms requiring iterative paracenteses. Intraperitoneal perfusion of mitomycin-C and cisplatin was delivered for 60-90 min with an inflow temperature of 45 degrees C. Results: Complete clinical regression of ascites and related symptoms was achieved in all the five patients treated. Intraoperative course was uneventful in all cases. Mean operative time was 181 min. No postoperative deaths, related to the procedure, occurred. Only a case of delayed gastric empting was recorded as a minor postoperative complication. Conclusions: Laparoscopic HIPEC appears to be a safe and effective procedure to treat debilitating malignant ascites from unresectable peritoneal carcinomatosis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：154 / 158

页数：5

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