Cellular expression of bovine herpesvirus 1 gD inhibits cell-to-cell spread of two closely related viruses without blocking their primary infection

被引:18
作者
Dasika, GK [1 ]
Letchworth, GJ [1 ]
机构
[1] Univ Wisconsin, Madison, WI 53706 USA
关键词
D O I
10.1006/viro.1998.9553
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Alphaherpesviral glycoprotein D (gD) is a critical component of the cell membrane penetration system. Cells that express go of herpes simplex virus type 1 (HSV1), pseudorabies virus (PRV), or bovine herpesvirus type 1.1 (BHV1.1) resist infection by the homologous virus due to interference with viral entry at the level of penetration. BHV1.1 go interferes with the distantly related viruses HSV1 and PRV despite only a 30-40% sequence similarity and the complete absence of antigenic crossreactivity among the three gDs. The six cysteines that form three intrachain disulfide bonds in HSV1 are also present in PRV and BHV1.1 go, suggesting structural similarities among the go homologs. Functional similarities were postulated to be responsible for cross-interference. To test this hypothesis, we constructed a BHV1.1 go-expressing cell line (MDBKgD) and assessed its resistance to the homologous BHV1.1 and two closely related viruses, BHV1.2 and BHV5. The gDs of these viruses share 98.3% and 86% amino acid identity with BHV1.1 go and bound monoclonal antibodies directed against all five neutralizing epitopes mapped on BHV1.1 go. MDBKgD cells were resistant to BHV1.1 but fully susceptible to BHV1.2 and BHV5 infection as measured by plaque numbers and single cycle growth kinetics. However,all three viruses, but not vesicular stomatitis virus, made smaller plaques on MDBKgD cells than on control cells. These data suggest that go-mediated interference is expressed both at the level of initial infection and at the level of cell-to-cell spread and that these two levels can be distinguished by using closely related viruses, (C) 1999 Academic Press.
引用
收藏
页码:24 / 36
页数:13
相关论文
共 58 条
[1]   FINE MAPPING OF BOVINE HERPESVIRUS-1 (BHV-1) GLYCOPROTEIN-D (GD) NEUTRALIZING EPITOPES BY TYPE-SPECIFIC MONOCLONAL-ANTIBODIES AND SEQUENCE COMPARISON WITH BHV-5 GD [J].
ABDELMAGID, OY ;
MINOCHA, HC ;
COLLINS, JK ;
CHOWDHURY, SI .
VIROLOGY, 1995, 206 (01) :242-253
[2]   MAPPING OF HERPES-SIMPLEX VIRUS-1 GENES WITH MUTATIONS WHICH OVERCOME HOST RESTRICTIONS TO INFECTION [J].
BRANDIMARTI, R ;
HUANG, TM ;
ROIZMAN, B ;
CAMPADELLIFIUME, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5406-5410
[3]   ROLE OF MANNOSE-6-PHOSPHATE RECEPTORS IN HERPES-SIMPLEX VIRUS ENTRY INTO CELLS AND CELL-TO-CELL TRANSMISSION [J].
BRUNETTI, CR ;
BURKE, RL ;
HOFLACK, B ;
LUDWIG, T ;
DINGWELL, KS ;
JOHNSON, DC .
JOURNAL OF VIROLOGY, 1995, 69 (06) :3517-3528
[4]   HERPES-SIMPLEX VIRUS GLYCOPROTEIN-D IS SUFFICIENT TO INDUCE SPONTANEOUS PH-INDEPENDENT FUSION IN A CELL-LINE THAT CONSTITUTIVELY EXPRESSES THE GLYCOPROTEIN [J].
CAMPADELLIFIUME, G ;
AVITABILE, E ;
FINI, S ;
STIRPE, D ;
ARSENAKIS, M ;
ROIZMAN, B .
VIROLOGY, 1988, 166 (02) :598-602
[5]   GLYCOPROTEIN-D OF HERPES-SIMPLEX VIRUS ENCODES A DOMAIN WHICH PRECLUDES PENETRATION OF CELLS EXPRESSING THE GLYCOPROTEIN BY SUPERINFECTING HERPES-SIMPLEX VIRUS [J].
CAMPADELLIFIUME, G ;
QI, S ;
AVITABILE, E ;
FOATOMASI, L ;
BRANDIMARTI, R ;
ROIZMAN, B .
JOURNAL OF VIROLOGY, 1990, 64 (12) :6070-6079
[6]   ENTRY OF HERPES-SIMPLEX VIRUS-1 IN BJ CELLS THAT CONSTITUTIVELY EXPRESS VIRAL GLYCOPROTEIN D IS BY ENDOCYTOSIS AND RESULTS IN DEGRADATION OF THE VIRUS [J].
CAMPADELLIFIUME, G ;
ARSENAKIS, M ;
FARABEGOLI, F ;
ROIZMAN, B .
JOURNAL OF VIROLOGY, 1988, 62 (01) :159-167
[7]   BOVINE CELLS EXPRESSING BOVINE HERPESVIRUS 1 (BHV-1) GLYCOPROTEIN-IV RESIST INFECTION BY BHV-1, HERPES-SIMPLEX VIRUS, AND PSEUDORABIES VIRUS [J].
CHASE, CCL ;
CARTERALLEN, K ;
LOHFF, C ;
LETCHWORTH, GJ .
JOURNAL OF VIROLOGY, 1990, 64 (10) :4866-4872
[8]   BOVINE HERPESVIRUS-1 GIV-EXPRESSING CELLS RESIST VIRUS PENETRATION [J].
CHASE, CCL ;
LETCHWORTH, GJ .
JOURNAL OF GENERAL VIROLOGY, 1994, 75 :177-181
[9]   RESISTANCE AND SUSCEPTIBILITY OF BOVINE CELLS EXPRESSING HERPESVIRAL GLYCOPROTEIN-D HOMOLOGS TO HERPESVIRAL INFECTIONS [J].
CHASE, CCL ;
LOHFF, C ;
LETCHWORTH, GJ .
VIROLOGY, 1993, 194 (01) :365-369
[10]   ANALYSIS OF THE CONTRIBUTIONS OF HERPES-SIMPLEX VIRUS TYPE-1 MEMBRANE-PROTEINS TO THE INDUCTION OF CELL-CELL FUSION [J].
DAVISPOYNTER, N ;
BELL, S ;
MINSON, T ;
BROWNE, H .
JOURNAL OF VIROLOGY, 1994, 68 (11) :7586-7590