Cerebrovascular muscle atrophy is a feature of Alzheimer's disease

被引：55

作者：

Perry, G

Smith, MA

McCann, CE

Siedlak, SL

Jones, PK

Friedland, RP

机构：

[1] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Neurol, Cleveland, OH 44106 USA

来源：

BRAIN RESEARCH | 1998年 / 791卷 / 1-2期

关键词：

amyloid-beta; beta protein precursor; hypoperfusion; oxidative stress; vasculature atrophy;

D O I：

10.1016/S0006-8993(98)00006-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined vascular amyloid-beta deposition and other abnormalities in the posterior cerebral artery of consecutive cases of Alzheimer's disease (AD) compared to controls. Smooth muscle atrophy was a consistent feature in the cases of AD examined (p < 0.01) and was surprisingly independent of adjacent amyloid-beta deposition. These findings suggest that vascular abnormalities are a consistent feature in AD and may be an important contributor to the pathogenesis and complications of AD. (C) 1998 Elsevier Science B.V.

引用

页码：63 / 66

页数：4

共 25 条

[1] DEGENERATION OF SMOOTH-MUSCLE CELLS IN BETA-AMYLOID ANGIOPATHIES [J].