Heat shock protein expression in human tumours grown in severe combined immunodeficient mice

被引：18

作者：

Katoh, M

Koninkx, J

Schumacher, U

机构：

[1] Univ Hamburg, Hosp Eppendorf, Inst Anat, D-20246 Hamburg, Germany

[2] Univ Utrecht, Fac Vet Med, Dept Pathol, NL-3508 TD Utrecht, Netherlands

来源：

CANCER LETTERS | 2000年 / 161卷 / 01期

关键词：

heat shock protein; severe combined immunodeficient mice; breast cancer; colon cancer; chemotherapy;

D O I：

10.1016/S0304-3835(00)00601-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The constitutional expression of heat shock proteins (HSP) 27, 70 and 90 in human breast, colon and ovarian cancer cells transplanted into severe combined immunodeficient (SCID) mice was evaluated. In addition their induced expression under chemotherapeutic stress was analyzed. The oestrogen receptor positive breast cancer cell lines (MCF-7, T47D) demonstrated an increased level of HSP 27 and 70 expression compared with oestrogen receptor negative cell lines (BT20, HBL100). After 5-fluorouracil application for 4 days, HSP 27 and 70 expression was increased in HT29 colon tumours. Hence, the human/SCID mouse model is well suited to evaluate the constitutional and induced expression of human HSPs under various experimental conditions. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 120

页数：8

共 37 条

[1] Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta [J].