Prostaglandins and Inflammation

被引：2665

作者：

Ricciotti, Emanuela ^{[1
]}

FitzGerald, Garret A. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 05期

基金：

美国国家卫生研究院;

关键词：

eicosanoids; prostacyclin; prostaglandins; thromboxanes; SMOOTH-MUSCLE-CELLS; ENDOTHELIUM-DEPENDENT CONTRACTIONS; COLLAGEN-INDUCED ARTHRITIS; RECEPTOR-DEFICIENT MICE; NITRIC-OXIDE SYNTHASE; ALLERGIC INFLAMMATION; THROMBOXANE A(2); PROSTACYCLIN RECEPTOR; IN-VIVO; PROSTANOID RECEPTORS;

D O I：

10.1161/ATVBAHA.110.207449

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated from arachidonate by the action of cyclooxygenase isoenzymes, and their biosynthesis is blocked by nonsteroidal antiinflammatory drugs, including those selective for inhibition of cyclooxygenase-2. Despite the clinical efficacy of nonsteroidal antiinflammatory drugs, prostaglandins may function in both the promotion and resolution of inflammation. This review summarizes insights into the mechanisms of prostaglandin generation and the roles of individual mediators and their receptors in modulating the inflammatory response. Prostaglandin biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm. (Arterioscler Thromb Vasc Biol. 2011;31:986-1000.)

引用

页码：986 / 1000

页数：15

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