Proteome complexity and the forces that drive proteome imbalance

被引：198

作者：

Harper, J. Wade ^{[1
]}

Bennett, Eric J. ^{[2
]}

机构：

[1] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

[2] Univ Calif San Diego, Sect Cell & Dev Biol, Div Biol Sci, La Jolla, CA 92093 USA

来源：

NATURE | 2016年 / 537卷 / 7620期

基金：

美国国家卫生研究院;

关键词：

N-TERMINAL ACETYLATION; UBIQUITIN-PROTEASOME-SYSTEM; EMBRYONIC STEM-CELLS; QUALITY-CONTROL; COPY-NUMBER; AAA-ATPASE; COTRANSLATIONAL UBIQUITINATION; SACCHAROMYCES-CEREVISIAE; TRANSLATION INITIATION; RIBOSOME BIOGENESIS;

D O I：

10.1038/nature19947

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.

引用

页码：328 / 338

页数：11

共 136 条

[1]

EFFECT OF RP51 GENE DOSAGE ALTERATIONS ON RIBOSOME SYNTHESIS IN SACCHAROMYCES-CEREVISIAE [J].

ABOVICH, N ;

GRITZ, L ;

TUNG, L ;

ROSBASH, M .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (12) :3429-3435

[2]

A global reference for human genetic variation [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Wang, Jun ;

Wilson, Richard K. ;

Boerwinkle, Eric ;

Doddapaneni, Harsha ;

Han, Yi ;

Korchina, Viktoriya ;

Kovar, Christie ;

Lee, Sandra ;

Muzny, Donna ;

Reid, Jeffrey G. ;

Zhu, Yiming ;

Chang, Yuqi ;

Feng, Qiang ;

Fang, Xiaodong ;

Guo, Xiaosen ;

Jian, Min ;

Jiang, Hui ;

Jin, Xin ;

Lan, Tianming ;

Li, Guoqing ;

Li, Jingxiang ;

Li, Yingrui ;

Liu, Shengmao ;

Liu, Xiao ;

Lu, Yao ;

Ma, Xuedi ;

Tang, Meifang ;

Wang, Bo .

NATURE, 2015, 526 (7571) :68-+

[3]

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis [J].

Anderson, Daniel J. ;

Le Moigne, Ronan ;

Djakovic, Stevan ;

Kumar, Brajesh ;

Rice, Julie ;

Wong, Steve ;

Wang, Jinhai ;

Yao, Bing ;

Valle, Eduardo ;

von Soly, Szerenke Kiss ;

Madriaga, Antonett ;

Soriano, Ferdie ;

Menon, Mary-Kamala ;

Wu, Zhi Yong ;

Kampmann, Martin ;

Chen, Yuwen ;

Weissman, Jonathan S. ;

Aftab, Blake T. ;

Yakes, F. Michael ;

Shawver, Laura ;

Zhou, Han-Jie ;

Wustrow, David ;

Rolfe, Mark .

CANCER CELL, 2015, 28 (05) :653-665

[4]

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans [J].

Arnesen, Thomas ;

Van Damme, Petra ;

Polevoda, Bogdan ;

Helsens, Kenny ;

Evjenth, Rune ;

Colaert, Niklaas ;

Varhaug, Jan Erik ;

Vandekerckhove, Joel ;

Lillehaug, Johan R. ;

Sherman, Fred ;

Gevaert, Kris .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (20) :8157-8162

[5]

A molecular census of 26S proteasomes in intact neurons [J].

Asano, Shoh ;

Fukuda, Yoshiyuki ;

Beck, Florian ;

Aufderheide, Antje ;

Foerster, Friedrich ;

Danev, Radostin ;

Baumeister, Wolfgang .

SCIENCE, 2015, 347 (6220) :439-442

[6]

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells [J].

Avdulov, S ;

Li, S ;

Michalek, V ;

Burrichter, D ;

Peterson, M ;

Perlman, DM ;

Manivel, JC ;

Sonenberg, N ;

Yee, D ;

Bitterman, PB ;

Polunovsky, VA .

CANCER CELL, 2004, 5 (06) :553-563

[7]

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency [J].

Barna, Maria ;

Pusic, Aya ;

Zollo, Ornella ;

Costa, Maria ;

Kondrashov, Nadya ;

Rego, Eduardo ;

Rao, Pulivarthi H. ;

Ruggero, Davide .

NATURE, 2008, 456 (7224) :971-U79

[8]

Inflating bacterial cells by increased protein synthesis [J].

Basan, Markus ;

Zhu, Manlu ;

Dai, Xiongfeng ;

Warren, Mya ;

Sevin, Daniel ;

Wang, Yi-Ping ;

Hwa, Terence .

MOLECULAR SYSTEMS BIOLOGY, 2015, 11 (10)

[9]

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control [J].

Bengtson, Mario H. ;

Joazeiro, Claudio A. P. .

NATURE, 2010, 467 (7314) :470-473

[10]

The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

← 1 2 3 4 5 6 7 8 9 10 →