Ten Years of Global Evolution of the Human Respiratory Syncytial Virus BA Genotype with a 60-Nucleotide Duplication in the G Protein Gene

被引:153
作者
Trento, Alfonsina [1 ,4 ]
Casas, Inmaculada [2 ]
Calderon, Ana [2 ]
Garcia-Garcia, Maria L. [3 ]
Calvo, Cristina [3 ]
Perez-Brena, Pilar [2 ]
Melero, Jose A. [1 ,4 ]
机构
[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Biol Viral, Madrid 28220, Spain
[2] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Virus Resp, Madrid 28220, Spain
[3] Severo Ochoa Hosp, Dept Pediat, Madrid 28911, Spain
[4] Inst Salud Carlos III, CIBERES, Madrid 28220, Spain
关键词
MOLECULAR EPIDEMIOLOGIC ANALYSIS; SUBGROUP-A; G-GLYCOPROTEIN; CIRCULATION PATTERNS; TRACT INFECTIONS; ANTIGENIC STRUCTURE; CLINICAL CHARACTERISTICS; KILIFI DISTRICT; CHILDREN; SEQUENCE;
D O I
10.1128/JVI.00345-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The emergence of natural isolates of human respiratory syncytial virus group B (HRSV-B) with a 60-nucleotide (nt) duplication in the G protein gene in Buenos Aires, Argentina, in 1999 (A. Trento et al., J. Gen. Virol. 84: 3115-3120, 2003) and their dissemination worldwide allowed us to use the duplicated segment as a natural tag to examine in detail the evolution of HRSV during propagation in its natural host. Viruses with the duplicated segment were all clustered in a new genotype, named BA (A. Trento et al., J. Virol. 80:975-984, 2006). To obtain information about the prevalence of these viruses in Spain, we tested for the presence of the duplicated segment in positive HRSV-B clinical samples collected at the Severo Ochoa Hospital (Madrid) during 12 consecutive epidemics (1996-1997 to 2007-2008). Viruses with the 60-nt duplication were found in 61 samples, with a high prevalence relative to the rest of B genotypes in the most recent seasons. Global phylogenetic and demographic analysis of all G sequences containing the duplication, collected across five continents up until April 2009, revealed that the prevalence of the BA genotype increased gradually until 2004-2005, despite its rapid dissemination worldwide. After that date and coinciding with a bottleneck effect on the population size, a relatively new BA lineage (BA-IV) replaced all other group B viruses, suggesting further adaptation of the BA genotype to its natural host.
引用
收藏
页码:7500 / 7512
页数:13
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