Reciprocal Th1 and Th17 Regulation by Mesenchymal Stem Cells: Implication for Multiple Sclerosis

被引：72

作者：

Darlington, Peter J. ^{[1
]}

Boivin, Marie-Noelle ^{[1
]}

Renoux, Christel ^{[2
]}

Francois, Moira ^{[3
,4
]}

Galipeau, Jacques ^{[5
]}

Freedman, Mark S. ^{[6
]}

Atkins, Harold L. ^{[7
]}

Cohen, Jeffrey A. ^{[8
]}

Solchaga, Luis ^{[9
,10
]}

Amit-Bar-Or ^{[1
,11
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, Neuroimmunol Unit, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Ctr Clin Epidemiol, Jewish Gen Hosp, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Lady Davis Inst, Montreal, PQ H3A 2B4, Canada

[4] McGill Univ, Dept Expt Med, Montreal, PQ H3A 2B4, Canada

[5] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[6] Ottawa Gen Hosp, Dept Neurol, Ottawa, ON K1H 8L6, Canada

[7] Ottawa Gen Hosp, Blood & Marrow Transplant Program, Ottawa, ON K1H 8L6, Canada

[8] Cleveland Clin, Mellen MS Ctr, Neurol Inst, Cleveland, OH 44106 USA

[9] Case Comprehens Canc Ctr, Cleveland, OH USA

[10] Case Western Reserve Univ, Dept Gen Med Sci Oncol, Cleveland, OH 44106 USA

[11] McGill Univ, Montreal Neurol Inst, Expt Therapeut Program, Montreal, PQ H3A 2B4, Canada

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 04期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; INTERFERON-GAMMA; DISEASE-ACTIVITY; STROMAL CELLS; T-CELLS; IMMUNOSUPPRESSION; RESPONSES; INHIBIT; PROMOTE;

D O I：

10.1002/ana.22065

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Human mesenchymal stem cells (hMSCs) are being considered for clinical trials of multiple sclerosis (MS). We examined the effects of adult bone marrow-derived hMSCs on responses of primary human Th1, Th17, and Th1/17 double-expressing T-cell subsets, all implicated in MS. As expected, soluble products from hMSCs inhibited Th1 responses; however, Th17 responses were increased. Secretion of interleukin (IL)-10, considered anti-inflammatory, was decreased. Pretreating hMSCs with the proinflammatory cytokine IL-1 beta accentuated these effects, and caused decreases in the Th1/17 subset. These findings underscore the importance of further preclinical work and immune-monitoring to define hMSC effects on disease-relevant immune responses under variable conditions. ANN NEUROL 2010;68:540-545

引用

页码：540 / 545

页数：6

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