Modulation factors of oxidative status in stable renal transplantation

被引:33
作者
Moreno, JM
Ruiz, MC [1 ]
Ruiz, N
Gomez, I
Vargas, F
Asensio, C
Osuna, A
机构
[1] HU Virgen de las Nieves, Serv Nefrol, Granada 18014, Spain
[2] Univ Jaen, Dept Stat, Jaen, Spain
[3] Univ Granada, Dept Physiol, Granada, Spain
关键词
D O I
10.1016/j.transproceed.2005.02.037
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Reactive oxygen species (ROS) trigger a biomolecular alteration that causes functional and structural changes. In renal transplantation, there is an increase in oxidative phenomena related to endothelial dysfunction, inflammation, and atherosclerosis, the main cause of cardiovascular complications and chronic allograft failure. The present study was designed to assess the oxidative state of transplant patients with stable renal function, in order to establish differences in oxidative, biochemical, and clinical parameters between patients treated with tacrolimus versus cyclosporine. We studied 67 stable kidney transplant patients treated with calcineurin inhibitors who were not receiving cholesterol-lowering therapy, and 14 healthy subjects. Data were collected on biochemical parameters: lipid profile (apoA, apoB, total cholesterol and fractions, and triglycerides); urea; and creatinine; oxidative parameters: malondialdehyde (MDA) as a lipid peroxidation marker, glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD), glutathione reductase (GR), and antibodies against oxidized LDL; and clinical variables. Transplanted patients showed a higher oxidative status (MDA increase and GPx decrease) than healthy subjects. The oxidative status did not differ between the cyclosporine and tacrolimus cohorts. Some factors during the posttransplant period, such as delayed graft function, cytomegalovirus infection, and microalbuminuria, which may damage renal function, produce a decreased antioxidant capacity (lower GPx).
引用
收藏
页码:1428 / 1430
页数:3
相关论文
共 11 条
[1]   Hyperlipidaemia in renal transplant patients [J].
Aakhus, S ;
Dahl, K ;
Wideroe, TE .
JOURNAL OF INTERNAL MEDICINE, 1996, 239 (05) :407-415
[2]   Lipid peroxidation and cytokines in chronic allograft failure: Influence of nonimmunological risk factors [J].
Boratynska, M ;
Boratynski, J ;
Klinger, M ;
Szyber, P ;
Pawlowski, S ;
Pupka, A ;
Zdrojowy, Z ;
Dembowski, J .
TRANSPLANTATION PROCEEDINGS, 2000, 32 (06) :1384-1386
[3]   Oxidative stress and lipid abnormalities in renal transplant recipients with or without chronic rejection [J].
Cristol, JP ;
Vela, C ;
Maggi, MF ;
Descomps, B ;
Mourad, G .
TRANSPLANTATION, 1998, 65 (10) :1322-1328
[4]   Oxidative stress in chronic renal failure [J].
Galle, J .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (11) :2135-2137
[5]   Human cytomegalovirus seropositivity is associated with impaired vascular function [J].
Grahame-Clarke, C ;
Chan, NN ;
Andrew, D ;
Ridgway, GL ;
Betteridge, DJ ;
Emery, V ;
Colhoun, HM ;
Vallance, P .
CIRCULATION, 2003, 108 (06) :678-683
[6]   Hyperlipidemia in solid organ transplantation [J].
Kobashigawa, JA ;
Kasiske, BL .
TRANSPLANTATION, 1997, 63 (03) :331-338
[7]  
Lash LH, 2001, J PHARMACOL EXP THER, V296, P243
[8]   Low-density lipoprotein composition and oxidation are not influenced by calcineurin inhibitors in renal transplant patients [J].
Morena, M ;
Vela, C ;
Garrigue, V ;
Catanzano, J ;
Descomps, B ;
Cristol, JP ;
Mourad, G .
TRANSPLANTATION PROCEEDINGS, 2000, 32 (08) :2785-2786
[9]   Kidney disease as a risk factor for development of cardiovascular disease - A statement from the American Heart Association councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention [J].
Sarnak, MJ ;
Levey, AS ;
Schoolwerth, AC ;
Coresh, J ;
Culleton, B ;
Hamm, LL ;
McCullough, PA ;
Kasiske, BL ;
Kelepouris, E ;
Klag, MJ ;
Parfrey, P ;
Pfeffer, M ;
Raij, L ;
Spinosa, DJ ;
Wilson, PW .
CIRCULATION, 2003, 108 (17) :2154-2169
[10]  
Steinerová A, 2001, PHYSIOL RES, V50, P131