In vitro activity of linezolid against multidrug-resistant Mycobacterium tuberculosis isolates

被引：35

作者：

Erturan, Z ^{[1
]}

Uzun, M ^{[1
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Microbiol & Clin Microbiol, TR-34390 Istanbul, Turkey

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2005年 / 26卷 / 01期

关键词：

linezolid; Mycobacterium tuberculosis; multidrug-resistant;

D O I：

10.1016/j.ijantimicag.2005.03.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Information in the literature regarding the activity of linezolid against multidrug-resistant (MDR) Mycobacterium tuberculosis strains is scarce. We therefore tested the in vitro activity of this drug against 39 MDR M. tuberculosis strains isolated from clinical specimens using the Bactec (R) 460 TB system. All strains were inhibited by <= 8 mg/L (minimum inhibitory concentration (MIC); MIC50 = 4 mg/L, MIC50 = 8 mg/L). Although the MIC values are higher than in other studies, based on proposed breakpoints all strains were found to be susceptible to linezolid. Further investigations to prove its usefulness in the treatment of MDR tuberculosis should be carried out. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：78 / 80

页数：3

共 11 条

[1] In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs [J].

Alcalá, L ;

Ruiz-Serrano, MJ ;

Turégano, CPF ;

Garcia de Viedma, D ;

Díaz-Infantes, M ;

Marín-Arriaza, M ;

Bouza, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :416-417

[2] Oxazolidinones: activity, mode of action, and mechanism of resistance [J].

Bozdogan, B ;

Appelbaum, PC .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 23 (02) :113-119

[3] Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model [J].

Cynamon, MH ;

Klemens, SP ;

Sharpe, CA ;

Chase, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) :1189-1191

[4] Standard short-course chemotherapy for drug-resistant tuberculosis -: Treatment outcomes in 6 countries [J].

Espinal, MA ;

Kim, SJ ;

Suarez, PG ;

Kam, KM ;

Khomenko, AG ;

Migliori, GB ;

Baéz, J ;

Kochi, A ;

Dye, C ;

Raviglione, MC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (19) :2537-2545

[5] The global situation of MDR-TB [J].

Espinal, MA .

TUBERCULOSIS, 2003, 83 (1-3) :44-51

[6]

HADJIANGELIS NP, 2003, AM J RESP CRIT CARE, V167, pA868

[7] Multicenter laboratory validation of susceptibility testing of Mycobacterium tuberculosis against classical second-line and newer antimicrobial drugs by using the radiometric BACTEC 460 technique and the proportion method with solid media [J].

Pfyffer, GE ;

Bonato, DA ;

Ebrahimzadeh, A ;

Gross, W ;

Hotaling, J ;

Kornblum, J ;

Laszlo, A ;

Roberts, G ;

Salfinger, M ;

Wittwer, F ;

Siddiqi, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (10) :3179-3186

[8] In vitro activity of moxifloxacin, levofloxacin, gatifloxacin and linezolid against Mycobacterium tuberculosis [J].

Rodríguez, JC ;

Ruiz, M ;

López, M ;

Royo, G .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2002, 20 (06) :464-467

[9]

Schluger NW, 2000, INT J TUBERC LUNG D, V4, pS71

[10] Activities of linezolid against rapidly growing mycobacteria [J].

Wallace, RJ ;

Brown-Elliott, BA ;

Ward, SC ;

Crist, CJ ;

Mann, LB ;

Wilson, RW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (03) :764-767

← 1 2 →