The role of clusterin in in vitro ischemia of human retinal endothelial cells

被引：47

作者：

Kim, Jeong Hun

Yu, Young Suk

Kim, Jin Hyoung

Kim, Kyu-Won

Min, Bon-Hong

机构：

[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Ophthalmol, Seoul 110744, South Korea

[2] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Seoul Artificial Eye Ctr,Clin Res Inst,Dept O, Seoul, South Korea

[3] Seoul Natl Univ, Coll Pharm, Neurovasc Coordinat Res Ctr, Pharmaceut Sci Res Inst, Seoul, South Korea

[4] Korea Univ, Coll Med, Dept Pharmacol, BK21 Program Med Sci, Seoul 136701, South Korea

来源：

CURRENT EYE RESEARCH | 2007年 / 32卷 / 7-8期

关键词：

clusterin; ischemia; endothelial cells; protective role; tight junction proteins;

D O I：

10.1080/02713680701487871

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Clusterin has been reported to be up- regulated in diverse pathophysiological stresses, but its role is controversial. In this study, we investigated the role of clusterin under in vitro ischemia of human retinal endothelial cells ( HRECs). When HRECs were exposed to oxygen- glucose deprivation ( OGD), clusterin expression increased, whereas von Willebrand factor ( vWF), occludin, and zonula occludens (ZO-1) markedly decreased. Interestingly, loss of tight junction proteins and death of HRECs in OGD conditions were restored by clusterin treatment. Our results suggest that the enhanced clusterin in OGD conditions may play a protective role against ischemia- induced tight junction protein loss and HRECs death.

引用

页码：693 / 698

页数：6

共 38 条

[1]

Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas [J].