Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue

被引：42

作者：

Cochen, V

Ribeiro, MJ

Nguyen, JP

Gurruchaga, JM

Villafane, G

Loc'h, C

Defer, G

Samson, Y

Peschanski, M

Hantraye, P

Cesaro, P

Remy, P ^{[1
]}

机构：

[1] CEA, Serv Hosp Frederic Joliot, CNRS, URA 2210, F-91401 Orsay, France

[2] CEA, Serv Hosp Frederic Joliot, Direct Sci Vivant, Dept Rech Med, F-91406 Orsay, France

[3] CHU Henri Mondor, Dept Neurosci, AP HP, F-94010 Creteil, France

[4] Univ Paris 07, Fac Med, Creteil, France

[5] Serv Neurol Dejerine, Caen, France

[6] Hop Henri Mondor, INSERM, Fac Med, U421, F-94010 Creteil, France

[7] CHU Pitie Salpetriere, Paris, France

来源：

MOVEMENT DISORDERS | 2003年 / 18卷 / 08期

关键词：

Parkinson; fetal transplantation; PET; dopamine transporter; CIT;

D O I：

10.1002/mds.10463

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared the striatal uptake of [F-18]fluorodopa with [Br-76]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [F-18]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [F-18]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [F-18]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation. (C) 2003 Movement Disorder Society.

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页码：928 / 932

页数：5

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