Cardiovascular actions of angiotensin-(1-7)

被引:147
作者
Ferreira, AJ
Santos, RAS
机构
[1] Univ Fed Minas Gerais, Dept Fisiol & Biofis, ICB, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Morfol, ICB, BR-31270901 Belo Horizonte, MG, Brazil
关键词
angiotensin-(1-7) receptor mas; renin-angiotensin system; cardiac function; blood vessels; angiotensin-converting enzyme 2; transgenic models;
D O I
10.1590/S0100-879X2005000400003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Angiotensin-(1-7) (Ang-(1-7)) is now considered to be a biologically active member of the renin-angiotensin system. The functions of Ang(1-7) are often opposite to those attributed to the main effector component of the renin-angiotensin system, Ang II. Chronic administration of angiotensin-converting enzyme inhibitors (ACEI) increases 10- to 25-fold the plasma levels of this peptide, suggesting that part of the beneficial effects of ACEI could be mediated by Ang-(1-7). Ang(1-7) can be formed from Ang II or directly from Ang I. Other enzymatic pathways for Ang-(1-7) generation have been recently described involving the novel ACE homologue ACE2. This enzyme can form Ang-(1-7) from Ang II or less efficiently by the hydrolysis of Ang I to Ang-(1-9) with subsequent Ang-(1-7) formation. The biological relevance of Ang-(1-7) has been recently reinforced by the identification of its receptor, the G-protein-coupled receptor Mas. Heart and blood vessels are important targets for the formation and actions of Ang-(1-7). In this review we will discuss recent findings concerning the biological role of Ang-(1-7) in the heart and blood vessels, taking into account aspects related to its formation and effects on these tissues. In addition, we will discuss the potential of Ang-(1-7) and its receptor as a target for the development of new cardiovascular drugs.
引用
收藏
页码:499 / 507
页数:9
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