Endothelial NOS: perspective and recent developments

被引：176

作者：

Garcia, Victor ^{[1
]}

Sessa, William C. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, Vasc Biol & Therapeut Program, New Haven, CT 06510 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2019年 / 176卷 / 02期

基金：

美国国家卫生研究院;

关键词：

NITRIC-OXIDE SYNTHASE; GROWTH-FACTOR; PHARMACOLOGY; 2017/18; CONCISE GUIDE; TRANSCRIPTIONAL INDUCTION; ENOS PHOSPHORYLATION; VASCULAR DYSFUNCTION; PULMONARY DEFECTS; HYDROGEN-SULFIDE; GENE-EXPRESSION;

D O I：

10.1111/bph.14522

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Endothelial NOS (eNOS), and its product NO, are vital components of the control of vasomotor function and cardiovascular homeostasis. In the present review, we will take a deep dive into eNOS enzymology, function and mechanisms regulating endothelial NO. The mechanisms regulating eNOS and NO synthesis discussed here include alterations to transcriptional, post-translational modifications and protein-protein regulations. Also, we will discuss the phenotypes associated with various eNOS mutants and the consequences of a disrupted eNOS/NO cascade, highlighting the importance of eNOS function and vascular homeostasis.

引用

页码：189 / 196

页数：8

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