Transient complete remission of acute lymphoblastic leukemia in relapse after allogeneic bone marrow transplantation induced by donor leukocyte transfusions

被引：3

作者：

DHondt, L

Chatelain, C

Doyen, C

Osselaer, JC

Ferrant, A

Bosly, A

机构：

[1] CLIN UNIV MT GODINNE,SERV HEMATOL & BIOL CLIN,B-5530 MONT GODINNE,BELGIUM

[2] CLIN UNIV ST LUC,SERV HEMATOL,B-1200 BRUSSELS,BELGIUM

来源：

HEMATOLOGY AND CELL THERAPY | 1996年 / 38卷 / 04期

关键词：

acute lymphoblastic leukemia; graft-vs-leukemia effect;

D O I：

10.1007/s00282-996-0353-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a young patient with refractory acute lymphoblastic leukemia relapse, after allogeneic bone marrow transplantation, who was treated by donor leukocyte infusions. We observed potent adoptive immunotherapy which produced a cytologic complete remission and total chimeric state. This was of short duration and the patient died of severe graft-versus-host disease. We present a short summary of the literature concerning acute lymphoblastic leukemia and donor leukocyte infusions.

引用

页码：353 / 354

页数：2

共 9 条

[1]

BAR BMAM, 1993, J CLIN ONCOL, V11, P513

[2]

DROBYSKI WR, 1993, BLOOD, V82, P2310

[3] GRAFT-VERSUS-LEUKEMIA EFFECT OF DONOR LYMPHOCYTE TRANSFUSIONS IN MARROW GRAFTED PATIENTS [J].

KOLB, HJ ;

SCHATTENBERG, A ;

GOLDMAN, JM ;

HERTENSTEIN, B ;

JACOBSEN, N ;

ARCESE, W ;

LJUNGMAN, P ;

FERRANT, A ;

VERDONCK, L ;

NIEDERWIESER, D ;

VANRHEE, F ;

MITTERMUELLER, J ;

DEWITTE, T ;

HOLLER, E ;

ANSARI, H .

BLOOD, 1995, 86 (05) :2041-2050

[4] DONOR LEUKOCYTE TRANSFUSIONS FOR TREATMENT OF RECURRENT CHRONIC MYELOGENOUS LEUKEMIA IN MARROW TRANSPLANT PATIENTS [J].

KOLB, HJ ;

MITTERMULLER, J ;

CLEMM, C ;

HOLLER, E ;

LEDDEROSE, G ;

BREHM, G ;

HEIM, M ;

WILMANNS, W .

BLOOD, 1990, 76 (12) :2462-2465

[5]

MACKINNON S, 1995, BONE MARROW TRANSPL, V15, P591

[6] ADOPTIVE IMMUNOTHERAPY EVALUATING ESCALATING DOSES OF DONOR LEUKOCYTES FOR RELAPSE OF CHRONIC MYELOID-LEUKEMIA AFTER BONE-MARROW TRANSPLANTATION - SEPARATION OF GRAFT-VERSUS-LEUKEMIA RESPONSES FROM GRAFT-VERSUS-HOST DISEASE [J].

MACKINNON, S ;

PAPADOPOULOS, EB ;

CARABASI, MH ;

REICH, L ;

COLLINS, NH ;

BOULAD, F ;

CASTROMALASPINA, H ;

CHILDS, BH ;

GILLIO, AP ;

KERNAN, NA ;

SMALL, TN ;

YOUNG, JW ;

OREILLY, RJ .

BLOOD, 1995, 86 (04) :1261-1268

[7]

ODOM LF, 1978, LANCET, V2, P537

[8]

SZER J, 1993, BONE MARROW TRANSPL, V11, P109

[9]

TAKAHASHI S, 1994, BLOOD S1, V84, P1339

← 1 →