Matrix metalloproteases and tumor invasion

被引:15
作者
Arribas, J [1 ]
机构
[1] Vall Hebron Univ Hosp Res Inst, Med Oncol Res Program, Barcelona, Spain
关键词
D O I
10.1056/NEJMcibr055002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A new study shows that a matrix metalloprotease cleaves the protease-activated receptor 1, thereby stimulating the migration and invasion of cancer cells. Copyright © 2005 Massachusetts Medical Society.
引用
收藏
页码:2020 / 2021
页数:2
相关论文
共 5 条
[1]   PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells [J].
Boire, A ;
Covic, L ;
Agarwal, A ;
Jacques, S ;
Sherifl, S ;
Kuliopulos, A .
CELL, 2005, 120 (03) :303-313
[2]   Thrombin signalling and protease-activated receptors [J].
Coughlin, SR .
NATURE, 2000, 407 (6801) :258-264
[3]   Cancer therapy - Matrix metalloproteinase inhibitors and cancer: Trials and tribulations [J].
Coussens, LM ;
Fingleton, B ;
Matrisian, LM .
SCIENCE, 2002, 295 (5564) :2387-2392
[4]   Thrombin receptor overexpression in malignant and physiological invasion processes [J].
Even-Ram, S ;
Uziely, B ;
Cohen, P ;
Grisaru-Granovsky, S ;
Maoz, M ;
Ginzburg, Y ;
Reich, R ;
Vlodavsky, I ;
Bar-Shavit, R .
NATURE MEDICINE, 1998, 4 (08) :909-914
[5]  
Kamath L, 2001, CANCER RES, V61, P5933