The helix-loop-helix transcription factor USF interacts with the basal promoter of human amyloid precursor protein

被引：12

作者：

Bourbonniere, M

Nalbantoglu, J

机构：

[1] MCGILL UNIV,DEPT NEUROL & NEUROSURG,MONTREAL,PQ H3A 2B4,CANADA

[2] MCGILL UNIV,MCGILL CTR STUDIES AGING,MONTREAL,PQ H3A 2B4,CANADA

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 35卷 / 1-2期

关键词：

amyloid precursor protein; promoter; E box; USF;

D O I：

10.1016/0169-328X(95)00208-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nuclear factors from HeLa, PC12, NG108-15 and SK-N-SH cell lines recognized an oligonucleotide (-56 to -37: APP-E1) containing an E box (CANNTG) which had previously been characterized as a DNase I-protected sequence in the basal promoter of the human amyloid precursor protein (APP) gene. Binding to APP-E1 was competed with an oligonucleotide encompassing the recognition site of the transcription factor USF. Antibodies directed against USF interacted with the APP-E1-protein complex and in vitro synthesized USF could bind APP-E1. Co-expression of USF cDNA transactivated a human APP-reporter gene construct. These results suggest that USF may play a role in the expression of the APP gene.

引用

页码：304 / 308

页数：5

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