The design and synthesis of non-peptide ligands with affinity and selectivity for tachykinin receptors.

被引：4

作者：

Horwell, DC ^{[1
]}

Morrell, AI ^{[1
]}

Roberts, E ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,PARKE DAVIS NEUROSCI RES CTR,CAMBRIDGE CB2 2QB,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 02期

关键词：

D O I：

10.1016/0960-894X(95)00582-E

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2,4-disubstituted morpholin-3-one based ligands which show affinity for tachykinin receptors have been designed and synthesised. Variation of the side chains attached to the central template gives rise to selectivity between receptor subtypes. This selectivity is directly analogous to that exhibited by dipeptide ligands for the same receptor subtypes.

引用

页码：165 / 166

页数：2

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