Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer

被引：102

作者：

Leung, WK ^{[1
]}

To, KF

Ng, YP

Lee, TL

Lau, JYW

Chan, FKL

Ng, EKW

Chung, SCS

Sung, J

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 03期

关键词：

cyclo-oxygenase-2; p53; gene; mutation; gastric cancer;

D O I：

10.1054/bjoc.2000.1607

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. (C) 2001 Cancer Research Campaign.

引用

页码：335 / 339

页数：5

共 23 条

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