Aging and cerebrovascular disease

被引:27
作者
Choi, JY
Morris, JC
Hsu, CY
机构
[1] Washington Univ, Barnes Jewish Hosp, Dept Neurol, Cerebrovasc Dis Sect, St Louis, MO USA
[2] Washington Univ, Barnes Jewish Hosp, Mem Diagnost Ctr, St Louis, MO USA
关键词
D O I
10.1016/S0733-8619(05)70089-X
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aging influences cerebrovascular disease expression by a variety of mechanisms. Age-related changes in cerebral autoregulation, cellular metabolism, the blood-brain barrier, and autonomic function may leave the cerebrovascular system vulnerable to injury. Certain cerebrovascular disease, such as atrial fibrillation, watershed infarctions, carotid artery atherosclerosis, cerebral hemorrhages, subdural hematomas, and transient global amnesia manifest in the elderly. Vascular dementia and white matter disease are better understood with newer neuroimaging studies, careful neuropsychological and histopathologic examinations. Atherosclerosis and cerebral amyloid angiopathy may have larger roles than previously understood in Alzheimer's disease.
引用
收藏
页码:687 / +
页数:26
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