Enzymatic resolution of bicyclo[n.1.0]alkan-1-ols derivatives:: Preparation of optically active α-substituted α-methylcycloalkanones.

被引：16

作者：

Morisson, V ^{[1
]}

Barnier, JP ^{[1
]}

Blanco, L ^{[1
]}

机构：

[1] Univ Paris 11, Inst Chim Mol Orsay, Lab Carbocycles, Associe CNRS, F-91405 Orsay, France

来源：

TETRAHEDRON | 1998年 / 54卷 / 27期

关键词：

D O I：

10.1016/S0040-4020(98)00411-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active alpha-methyl alpha-substituted cycloalkanones are prepared by a chemoenzymatic sequence which involves a Lipozyme(R)-catalyzed transesterification of 1-(chloroacetoxy)bicyclo[n.1.0]alkanes and ring opening of these cyclopropanol derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7749 / 7764

页数：16

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