A touching case of channel regulation:: the ATP-sensitive K+ channel

被引：42

作者：

Tucker, SJ ^{[1
]}

Ashcroft, FM ^{[1
]}

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(98)80055-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The classical type of K-ATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel.

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页码：316 / 320

页数：5

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共 48 条

[1] PROTEINS THAT INTERACT WITH THE PORE-FORMING SUBUNITS OF VOLTAGE-GATED ION CHANNELS [J].

ADELMAN, JP .

CURRENT OPINION IN NEUROBIOLOGY, 1995, 5 (03) :286-295

[2] CLONING OF THE BETA-CELL HIGH-AFFINITY SULFONYLUREA RECEPTOR - A REGULATOR OF INSULIN-SECRETION [J].

AGUILARBRYAN, L ;

NICHOLS, CG ;

WECHSLER, SW ;

CLEMENT, JP ;

BOYD, AE ;

GONZALEZ, G ;

HERRERASOSA, H ;

NGUY, K ;

BRYAN, J ;

NELSON, DA .

SCIENCE, 1995, 268 (5209) :423-426

[3] The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells [J].

Ammala, C ;

Moorhouse, A ;

Ashcroft, FM .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 494 (03) :709-714

[4] ELECTROPHYSIOLOGY OF THE PANCREATIC BETA-CELL [J].

ASHCROFT, FM ;

RORSMAN, P .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1989, 54 (02) :87-143

[5] PROPERTIES AND FUNCTIONS OF ATP-SENSITIVE K-CHANNELS [J].

ASHCROFT, SJH ;

ASHCROFT, FM .

CELLULAR SIGNALLING, 1990, 2 (03) :197-214

[6] GLUCOSE-INDUCED EXCITATION OF HYPOTHALAMIC NEURONS IS MEDIATED BY ATP-SENSITIVE K+ CHANNELS [J].

ASHFORD, MLJ ;

BODEN, PR ;

TREHERNE, JM .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1990, 415 (04) :479-483

[7] TOLBUTAMIDE EXCITES RAT GLUCORECEPTIVE VENTROMEDIAL HYPOTHALAMIC NEURONS BY INDIRECT INHIBITION OF ATP-K+ CHANNELS [J].

ASHFORD, MLJ ;

BODEN, PR ;

TREHERNE, JM .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (03) :531-540

[8] Evidence for a 65 kDa sulfonylurea receptor in rat pancreatic zymogen granule membranes [J].

Braun, M ;

Anderie, I ;

Thevenod, F .

FEBS LETTERS, 1997, 411 (2-3) :255-259

[9] Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular K-ATP channels [J].

Chutkow, WA ;

Simon, MC ;

LeBeau, MM ;

Burant, CF .

DIABETES, 1996, 45 (10) :1439-1445

[10] Association and stoichiometry of K-ATP channel subunits [J].

Clement, JP ;

Kunjilwar, K ;

Gonzalez, G ;

Schwanstecher, M ;

Panten, U ;

AguilarBryan, L ;

Bryan, J .

NEURON, 1997, 18 (05) :827-838

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