Understanding the cell biology of antigen presentation: the dendritic cell contribution

被引：33

作者：

Gatti, E ^{[1
]}

Pierre, P ^{[1
]}

机构：

[1] Univ Mediterranee, INSERM, CNRS, Ctr Immunol Marseille Luminy, F-13288 Marseille 9, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(03)00069-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The study of the cell biology of antigen processing and presentation has greatly contributed to our understanding of the immune response. The work of many immunologically inclined cell biologists has also permitted us to gain new insights on cellular mechanisms shared by many cell types. Dendritic cells are master regulators of the immune system and consequently have received a lot of attention in recent years. With the aim of controlling antigen processing and presentation, the solutions used by dendritic cells to respond to environmental changes are numerous and surprising. In the presence of pathogens, dendritic cells regulate strongly their endocytic pathway by interfering with uptake, proteolysis, membrane dynamics and transport in and out of the lysosome to become the most potent antigen-presenting cells known.

引用

页码：468 / 473

页数：6

共 52 条

[1] Nonclassical MHC class II molecules [J].

Alfonso, C ;

Karlsson, L .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :113-+

[2] Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation [J].

Anderson, HA ;

Hiltbold, EM ;

Roche, PA .

NATURE IMMUNOLOGY, 2000, 1 (02) :156-162

[3] MHC class II compartments in human dendritic cells undergo profound structural changes upon activation [J].

Barois, N ;

de Saint-Vis, B ;

Lebecque, S ;

Geuze, HJ ;

Kleijmeer, MJ .

TRAFFIC, 2002, 3 (12) :894-905

[4] Differential regulation of cathepsin S and cathepsin L in interferon γ-treated macrophages [J].

Beers, C ;

Honey, K ;

Fink, S ;

Forbush, K ;

Rudensky, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :169-179

[5] Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L [J].

Bevec, T ;

Stoka, V ;

Pungercic, G ;

Dolenc, I ;

Turk, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1331-1338

[6] Secretory lysosomes [J].

Blott, EJ ;

Griffiths, GM .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (02) :122-131

[7] T-cell engagement of dendritic cells rapidly rearranges MHC class II transport [J].

Boes, M ;

Cerny, J ;

Massol, R ;

Op den Brouw, M ;

Kirchhausen, T ;

Chen, JZ ;

Ploegh, HL .

NATURE, 2002, 418 (6901) :983-988

[8] Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells [J].

Cella, M ;

Engering, A ;

Pinet, V ;

Pieters, J ;

Lanzavecchia, A .

NATURE, 1997, 388 (6644) :782-787

[9] Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane [J].

Chow, A ;

Toomre, D ;

Garrett, W ;

Mellman, I .

NATURE, 2002, 418 (6901) :988-994

[10] Assembly of the immunological synapse for T cells and NK cells [J].

Davis, DM .

TRENDS IN IMMUNOLOGY, 2002, 23 (07) :356-363

← 1 2 3 4 5 6 →