Physical and transcript map of the dominant optic atrophy (OPA1) gene critical region at 3q28-q29

被引：2

作者：

Behnam, JT

Hamer, C

Spalton, D

Johnston, R

Seller, MJ

机构：

[1] Guys Hosp, Guys Kings & St Thomas Sch Med, Div Med & Mol Genet, London SE1 9RT, England

[2] St Thomas Hosp, Dept Ophthalmol, London SE1 7EH, England

[3] Moorfields Eye Hosp, London EC1V 2PD, England

来源：

GENOMICS | 2001年 / 72卷 / 02期

关键词：

D O I：

10.1006/geno.2000.6471

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The dominant optic atrophy gene (OPA1) has previously been mapped to chromosome 3q28-q29, We have now constructed a physical and transcriptional map across the OPA1 critical region between markers D3S3557 and D3S3346, It comprises 21 sequence-tagged sites (STSs), 4 single nucleotide polymorphisms, 29 expressed sequence tags, 2 known genes, and 12 newly generated STSs anchored onto 21 yeast artificial chromosome, 22 bacterial artificial chromosome, 48 P1 phage artificial chromosome, and 42 cosmid overlapping clones spanning 2.5 Rib. The map has allowed us to order many of the markers hitherto only roughly defined and to exclude 23 of the putative candidate genes assigned to the region, We found the OPA1 critical interval to be 450-550 kb, It contains 2 known genes, RPL35a and SDHA, which thus constitute candidate genes, (C) 2001 Academic Press.

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页码：213 / 216

页数：4

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