A role of mast cells for hepatic fibrosis in primary sclerosing cholangitis

被引:31
作者
Ishii, A
Iwai, M [1 ]
Harada, Y
Morikawa, T
Okanoue, T
Kishikawa, T
Tsuchihashi, Y
Hanai, K
Arizono, N
机构
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Gastroenterol Hepatol, Kyoto 6020841, Japan
[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Clin Pathol, Kyoto 6020841, Japan
[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Phys, Kyoto 6020841, Japan
[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Zool, Kyoto 6020841, Japan
关键词
primary sclerosing cholangitis; fibrosis; mast cells;
D O I
10.1016/j.hepres.2005.01.007
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We encountered four patients with overt primary sclerosing cholangitis (PSC) which were histologically classified into stage 2 or 3. We examined the expression of stem cell factor (SCF), a ligand of c-kit, in injured bile ducts by immunohistochemistry, and mast cells were identified by immunohistochemistry using anti-HMCT (human mast cell tryptase) and anti-e-kit antibodies to clarify their relation with portal fibrosis coincident with destroyed bile ducts. SCF was detected in the epithelia of most bile ducts in PSC, and many HMCT- and c-kit-positive mast cells were found in portal tracts. Image analysis showed more significant numbers of c-kit-positive mast cells per area of portal tract in PSC than in chronic hepatitis C, and they might increase from stage 2 to 3. c-Kit-positive cells infiltrated into the portal tracts with SCF-positive destroyed bile ducts, and c-kit mast cells should be investigated in detail to make a role for portal fibrosis in PSC. (c) 2005 Elsevier B.V All rights reserved.
引用
收藏
页码:127 / 131
页数:5
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