Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

被引：3699

作者：

Ginhoux, Florent ^{[1
,2
,3
]}

Greter, Melanie ^{[1
,2
]}

Leboeuf, Marylene ^{[1
,2
]}

Nandi, Sayan ^{[4
]}

See, Peter ^{[3
]}

Gokhan, Solen ^{[5
,6
]}

Mehler, Mark F. ^{[5
,6
,7
,8
,9
]}

Conway, Simon J. ^{[10
]}

Ng, Lai Guan ^{[3
]}

Stanley, E. Richard ^{[4
]}

Samokhvalov, Igor M. ^{[11
]}

Merad, Miriam ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[3] BIOPOLIS, Singapore Immunol Network SIgN, Singapore 138648, Singapore

[4] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[5] Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, Rose F Kennedy Ctr Res Intellectual & Dev Disabil, Bronx, NY 10461 USA

[6] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA

[7] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

[8] Albert Einstein Coll Med, Dept Psychiat, Bronx, NY 10461 USA

[9] Albert Einstein Coll Med, Dept Behav Sci, Bronx, NY 10461 USA

[10] Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[11] RIKEN Kobe, CDB, Lab Stem Cell Biol, Kobe, Hyogo 6500047, Japan

来源：

SCIENCE | 2010年 / 330卷 / 6005期

基金：

美国国家科学基金会;

关键词：

MOUSE BRAIN; YOLK-SAC; CELLS; RECEPTOR; ORIGIN; MICE; HEMATOPOIESIS; FRACTALKINE; PHAGOCYTES; MONOCYTES;

D O I：

10.1126/science.1194637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain. In contrast to many macrophage populations, we show that microglia develop in mice that lack colony stimulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice. In vivo lineage tracing studies established that adult microglia derive from primitive myeloid progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.

引用

页码：841 / 845

页数：5

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