Insulin resistance: Cellular and clinical concepts

被引：139

作者：

Cefalu, WT ^{[1
]}

机构：

[1] Univ Vermont, Coll Med, Dept Med, Endocrine Unit, Burlington, VT 05405 USA

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 226卷 / 01期

关键词：

insulin; type; 2; diabetes; atherosclerosis; insulin resistance; metabolic syndrome;

D O I：

10.1177/153537020122600103

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response. Specifically, the biologic response most studied is insulin-stimulated glucose disposal, yet the precise cellular mechanism responsible is not yet known. However, the presence of insulin resistance is observed many years before the onset of clinical hyperglycemia and the diagnosis of Type 2 diabetes. Insulin resistance at this stage appears to be significantly associated with a clustering of cardiovascular risk factors predisposing the individual to accelerated cardiovascular disease. An overview of insulin resistance and the associated clinical insulin resistant state will be discussed.

引用

页码：13 / 26

页数：14

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