Protein kinase signaling networks in cancer

被引：178

作者：

Brognard, John ^{[1
]}

Hunter, Tony ^{[2
]}

机构：

[1] Univ Manchester, Paterson Inst Canc Res, Canc Res UK, Signalling Networks Canc Grp, Manchester, Lancs, England

[2] Salk Inst Biol Studies, Mol & Cellular Biol Lab, La Jolla, CA USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2011年 / 21卷 / 01期

关键词：

SYNTHETIC LETHAL INTERACTIONS; CHRONIC MYELOGENOUS LEUKEMIA; PLECKSTRIN HOMOLOGY DOMAIN; SOMATIC MUTATIONS; TYROSINE KINASE; HUMAN BREAST; CELL PROLIFERATION; MYOSIN PHOSPHATASE; TUMOR-SUPPRESSOR; POINT MUTATION;

D O I：

10.1016/j.gde.2010.10.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein kinases orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. The complexity of numerous intracellular signaling pathways is highlighted by the number of kinases encoded by the human genome (539) and the plethora of phosphorylation sites identified in phosphoproteomic studies. Perturbation of these signaling networks by mutations or abnormal protein expression underlies the cause of many diseases including cancer. Recent RNAi screens and cancer genomic sequencing studies have revealed that many more kinases than anticipated contribute to tumorigenesis and are potential targets for inhibitor drug development intervention. This review will highlight recent insights into known pathways essential for tumorigenesis and discuss exciting new pathways for therapeutic intervention.

引用

页码：4 / 11

页数：8

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