Advances in the application of neuropeptides in insect control

被引：22

作者：

Altstein, M ^{[1
]}

Ben-Aziz, O

Schefler, I

Zeltser, I

Gilon, C

机构：

[1] Volcani Ctr, Inst Plant Protect, Dept Entomol, IL-50250 Bet Dagan, Israel

[2] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

来源：

CROP PROTECTION | 2000年 / 19卷 / 8-10期

关键词：

PBAN; insect neuropeptides; neuropeptide antagonists;

D O I：

10.1016/S0261-2194(00)00071-5

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The development of a new approach for the generation of a novel type of putative insect control agents based on backbone cyclic peptidomimetic antagonists of insect-neuropeptides is reported. The approach, termed the backbone cyclic neuropeptide based on antagonist (BBC-NBA) was applied to the insect pyrokinin/pheromone biosynthesis activating neuropeptide (PBAN) family as a model, and led to the discovery of a potent linear lead antagonist and several highly potent, metabolically stable BBC peptidomimetic antagonists, devoid of agonistic activity, which inhibited in vivo PBAN-mediated activities in moths. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：547 / 555

页数：9

共 78 条

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