Why do worms need cholesterol?

被引:145
作者
Kurzchalia, TV
Ward, S
机构
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[2] Univ Arizona, Tucson, AZ 85721 USA
关键词
CAENORHABDITIS-ELEGANS; C-ELEGANS; DEVELOPMENTAL AGE; NUCLEAR RECEPTOR; DROSOPHILA; REQUIREMENT; METABOLISM; GENETICS; STEROLS; ENCODES;
D O I
10.1038/ncb0803-684
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to have a major role in membrane structure. Instead, its most probable signalling functions are to control molting and induce a specialized non-feeding larval stage, although no cholesterol-derived signalling molecule has yet been identified for these or any other functions.
引用
收藏
页码:684 / 688
页数:5
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