Replicative helicase loaders: Ring breakers and ring makers

被引：77

作者：

Davey, MJ

O'Donnell, M

机构：

[1] Howard Hughes Med Inst, New York, NY 10021 USA

[2] Rockefeller Univ, New York, NY 10021 USA

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 15期

关键词：

D O I：

10.1016/S0960-9822(03)00523-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicase loaders transfer the ring-shaped replicative helicases onto DNA. They assort into two classes: ring breakers, which place stabile hexameric rings on DNA via transient gaps at subunit interfaces; and helicase makers, which assemble hexameric rings around DNA from monomeric helicase units.

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页码：R594 / R596

页数：3

相关论文

共 20 条

[1] A ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase protein [J].

Ahnert, P ;

Picha, KM ;

Patel, SS .

EMBO JOURNAL, 2000, 19 (13) :3418-3427

[2] DNA replication in eukaryotic cells [J].

Bell, SP ;

Dutta, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :333-374

[3] A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase [J].

Chong, JPJ ;

Hayashi, MK ;

Simon, MN ;

Xu, RM ;

Stillman, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1530-1535

[4] The DnaC helicase loader is a dual ATP/ADP switch protein [J].

Davey, MJ ;

Fang, LH ;

McInerney, P ;

Georgescu, RE ;

O'Donnell, M .

EMBO JOURNAL, 2002, 21 (12) :3148-3159

[5]

DEAN FB, 1992, J BIOL CHEM, V267, P14129

[6] THE PHAGE T4-CODED DNA-REPLICATION HELICASE (GP41) FORMS A HEXAMER UPON ACTIVATION BY NUCLEOSIDE TRIPHOSPHATE [J].

DONG, F ;

GOGOL, EP ;

VONHIPPEL, PH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) :7462-7473

[7]

FANNING E, 1992, ANNU REV BIOCHEM, V61, P55

[8] The structure and function of MCM from archaeal M-thermoautotrophicum [J].

Fletcher, RJ ;

Bishop, BE ;

Leon, RP ;

Sclafani, RA ;

Ogata, CM ;

Chen, XJS .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (03) :160-167

[9] A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex [J].

Ishimi, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) :24508-24513

[10] Assembly of the bacteriophage T4 helicase - Architecture and stoichiometry of the gp41-gp59 complex [J].

Ishmael, FT ;

Alley, SC ;

Benkovic, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) :20555-20562