The pathophysiology of hypertension - The importance of angiotensin II in cardiovascular remodeling

被引：43

作者：

Gibbons, GH

机构：

[1] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1998年 / 11卷 / 11期

关键词：

angiotensin II; hypertension; renin-angiotensin system;

D O I：

10.1016/S0895-7061(98)00198-8

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

Emerging data on the role of the tissue renin-angiotensin system are redefining our understanding of the pathophysiology of hypertension and other vascular disorders. Although the tissue renin-angiotensin system is quiescent after birth, it can be reactivated in response to tissue injury. Recent evidence suggests that this system is involved in maladaptive changes such as ventricular and vascular remodeling, alterations in renal function, and atherosclerosis. With increased recognition of the role of angiotensin II in these processes, new therapeutic opportunities are emerging. Blockade of angiotensin II will likely prove more effective than other vasodilator therapies in the setting of congestive heart failure and after acute myocardial infarction. Am J Hypertens 1998;11:177S-181S (C) 1998 American Journal of Hypertension, Ltd.

引用

页码：177S / 181S

页数：5

共 25 条

[1]

ASSOCIATION OF THE RENIN SODIUM PROFILE WITH THE RISK OF MYOCARDIAL-INFARCTION IN PATIENTS WITH HYPERTENSION [J].

ALDERMAN, MH ;

MADHAVAN, S ;

OOI, WL ;

COHEN, H ;

SEALEY, JE ;

LARAGH, JH .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (16) :1098-1104

[2]

Effects of the early administration of zofenopril on onset and progression of congestive heart failure in patients with anterior wall acute myocardial infarction [J].

Borghi, C ;

Ambrosioni, E ;

Magnani, B .

AMERICAN JOURNAL OF CARDIOLOGY, 1996, 78 (03) :317-322

[3]

Randomised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuria [J].

Chaturvedi, N ;

Stevenson, J ;

Fuller, JH ;

Rottiers, R ;

Ferriss, B ;

Karamanos, B ;

Kofinis, A ;

Petrou, C ;

IonescuTirgovisite, C ;

Iosif, C ;

Tamas, G ;

Bibok, G ;

Kerenyi, Z ;

KisGombos, P ;

Toth, J ;

Grealy, G ;

Priem, H ;

Koivisto, V ;

Tuominen, J ;

Kostamo, E ;

IdziorWalus, B ;

Solnica, B ;

GalickaLatalie, D ;

Michel, G ;

Keipes, M ;

Giuliani, A ;

Herode, A ;

Santeusanio, F ;

Bueti, A ;

Bistoni, S ;

Cagini ;

Navalesi, R ;

Penno, G ;

Nannipieri, M ;

Rizzo, L ;

Miccoli, R ;

Ghirlanda, G ;

Cotroneo, P ;

Manto, A ;

Minella, A ;

Saponara, C ;

Ward, J ;

Plater, M ;

Ibrahim, S ;

Ibbotson, S ;

Mody, C ;

Papazoglou, N ;

Manes, C ;

Soulis, K ;

Voukias, M .

LANCET, 1997, 349 (9068) :1787-1792

[4]

Danser AHJ, 1997, CIRCULATION, V96, P220

[5]

DEZEEUW D, 1995, CAN J CARDIOL, V11, pF41

[6]

Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease [J].

Diet, F ;

Pratt, RE ;

Berry, GJ ;

Momose, N ;

Gibbons, GH ;

Dzau, VJ .

CIRCULATION, 1996, 94 (11) :2756-2767

[7]

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice [J].

Esther, CR ;

Marino, EM ;

Howard, TE ;

Machaud, A ;

Corvol, P ;

Capecchi, MR ;

Bernstein, KE .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (10) :2375-2385

[8]

GANSEVOORT RT, 1995, NEPHROL DIAL TRANSPL, V10, P1963

[9]

GAVRAS H, 1981, LANCET, V2, P543

[10]

Overexpression of angiotensin AT(1) receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block [J].

Hein, L ;

Stevens, ME ;

Barsh, GS ;

Pratt, RE ;

Kobilka, BK ;

Dzau, VJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6391-6396

← 1 2 3 →