Arterial stiffness in renal patients: An update

被引：140

作者：

Covic, A

Gusbeth-Tatomir, P

Goldsmith, DJA

机构：

[1] C I Parhon Univ Hosp, Dialysis & Renal Transplantat Ctr, Iasi 6600, Romania

[2] Guys Hosp, Renal Unit, London SE1 9RT, England

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2005年 / 45卷 / 06期

关键词：

arterial stiffness; arterial calcification; augmentation index (AI); chronic kidney disease (CKD); end-stage renal disease (ESRD); pulse wave velocity (PWV);

D O I：

10.1053/j.ajkd.2005.02.026

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

According to recent data, arterial stiffness is a major independent risk factor for cardiovascular morbidity and mortality in both the general and renal populations. Because of several factors (vascular calcifications among them), large arteries are stiffer in patients with chronic kidney disease compared with the nonrenal population, contributing to the enormous cardiovascular mortality in renal patients. This review briefly analyzes methods for determination of arterial stiffness, focusing on 2 parameters, pulse wave velocity and the augmentation index, particularly useful in assessing arterial compliance in renal patients. Effects of different methods of renal replacement therapy on arterial wall properties also are discussed. Finally, the most promising novel and/or potential therapies regarding reduction of arterial stiffness in renal patients are reviewed. (c) 2005 by the National Kidney Foundation, Inc.

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收藏

页码：965 / 977

页数：13

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