Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice

被引：23

作者：

Andres, Allen M. ^{[2
]}

Ratliff, Eric P. ^{[2
]}

Sachithanantham, Sowbarnika ^{[2
]}

Hui, Simon T. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Cardiol, Dept Med, Los Angeles, CA 90095 USA

[2] San Diego State Univ, Dept Biol, BioSci Ctr, San Diego, CA 92182 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 08期

关键词：

Cellular AMP level; Mitochondrial oxidation; Glucose homeostasis; Glycogen storage; GLUCOSE-TRANSPORT; OXIDATIVE STRESS; GENE-EXPRESSION; KINASE; INSULIN; TXNIP; LKB1; IDENTIFICATION; DEFICIENCY; REGULATOR;

D O I：

10.1016/j.febslet.2011.03.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1223 / 1230

页数：8

共 42 条

[1]

Positional cloning of the combined hyperlipidemia gene Hyplip1 [J].

Bodnar, JS ;

Chatterjee, A ;

Castellani, LW ;

Ross, DA ;

Ohmen, J ;

Cavalcoli, J ;

Wu, CY ;

Dains, KM ;

Catanese, J ;

Chu, M ;

Sheth, SS ;

Charugundla, K ;

Demant, P ;

West, DB ;

de Jong, P ;

Lusis, AJ .

NATURE GENETICS, 2002, 30 (01) :110-116

[2]

Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA [J].

Chen, Julia Ling-Yu ;

Merl, Daniel ;

Peterson, Christopher W. ;

Wu, Jianli ;

Liu, Patrick Yantyng ;

Yin, Hanwei ;

Muoio, Deborah M. ;

Ayer, Don E. ;

West, Mike ;

Chi, Jen-Tsan .

PLOS GENETICS, 2010, 6 (09)

[3]

Expression of the AMP-activated protein kinase β1 and β2 subunits in skeletal muscle [J].

Chen, ZP ;

Heierhorst, J ;

Mann, RJ ;

Mitchelhill, KI ;

Michell, BJ ;

Witters, LA ;

Lynch, GS ;

Kemp, BE ;

Stapleton, D .

FEBS LETTERS, 1999, 460 (02) :343-348

[4]

Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production [J].

Chutkow, William A. ;

Patwari, Parth ;

Yoshioka, Jun ;

Lee, Richard T. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (04) :2397-2406

[5]

Deletion of the α-Arrestin Protein Tymip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity [J].

Chutkow, William A. ;

Birkenfeld, Andreas L. ;

Brown, Jonathan D. ;

Lee, Hui-Young ;

Frederick, David W. ;

Yoshioka, Jun ;

Patwari, Parth ;

Kursawe, Romy ;

Cushman, Samuel W. ;

Plutzky, Jorge ;

Shulman, Gerald I. ;

Samuel, Varman T. ;

Lee, Richard T. .

DIABETES, 2010, 59 (06) :1424-1434

[6]

Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle [J].

Derave, W ;

Ai, H ;

Ihlemann, J ;

Witters, LA ;

Kristiansen, S ;

Richter, EA ;

Ploug, T .

DIABETES, 2000, 49 (08) :1281-1287

[7]

AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle [J].

Furugen, Ayako ;

Kobayashi, Masaki ;

Narumi, Katsuya ;

Watanabe, Meguho ;

Otake, Sho ;

Itagaki, Shirou ;

Iseki, Ken .

LIFE SCIENCES, 2011, 88 (3-4) :163-168

[8]

SUITABILITY OF 2-DEOXYGLUCOSE FOR IN-VITRO MEASUREMENT OF GLUCOSE-TRANSPORT ACTIVITY IN SKELETAL-MUSCLE [J].

HANSEN, PA ;

GULVE, EA ;

HOLLOSZY, JO .

JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (02) :979-985

[9]

The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? [J].

Hardie, DG ;

Carling, D ;

Carlson, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :821-855

[10]

Regulation of the activity of the pyruvate dehydrogenase complex [J].

Harris, RA ;

Bowker-Kinley, MM ;

Huang, BL ;

Wu, PF .

ADVANCES IN ENZYME REGULATION, VOL 42, PROCEEDINGS, 2002, 42 :249-259

← 1 2 3 4 5 →