Regioselective enzymatic acylation of ribavirin to give potential multifunctional derivatives

被引：15

作者：

Liu, BK ^{[1
]}

Wang, N ^{[1
]}

Wu, Q ^{[1
]}

Xie, CY ^{[1
]}

Lin, XF ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 10期

关键词：

enzymatic synthesis; lipase; regioselectivity; ribavirin; vinyl ester;

D O I：

10.1007/s10529-005-5188-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lipase-catalyzed synthesis of potential multifunctional ribavirin derivatives was performed in acetone. Divinyl dicarboxylates with different chain lengths (C-4, C-6, C-9, C-10) were used as acyl donors and the reactions were catalyzed by lipase immobilized on acrylic resin from Candida antarctica (CAL-B). Ribavirin was regioselectivly acylated at the primary hydroxyl groups and the corresponding vinyl esters (C-4, C-6, C-9, C-10) were prepared in respective yields of 48%, 65%, 54%, 55%.

引用

页码：717 / 720

页数：4

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